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There is another way to prove that a high oxalates
level is a the result of
carbohydrate malabsorption:
Conduct an experiment by operating on humans and shortening
their GI tract in order to produce carbohydrate malabsorption and then see if that
results in high oxalate levels.
Well,such an awful operation has been done. Jejunoileal bypass surgery for obesity results in shortening of the digestive tract and carbohydrate malabsorption. Patients who had undergone this operation have higher levels of oxalates and kidney stones. They also have low levels of Oxalobacter formigenes ,the benficial bacteria that degrades oxalates. We therefore can guess that the carbohydrate malabsorption resulting from the jejunoileal bypass surgery provided lots of food for the other gut bugs who then crowded out the Oxalobacter formigenes,ate them up, or created a more acidic environment in which the Oxalobacter formigenes could not survive.
This tragic operation clarifies the role of carbohydrate malabsorption in reducing Oxalobacter formigenes and increasing oxalates.
This article proves that patients who undergo jejunoileal bypass surgery are much more likely to develop carbohydrate malabsorption.
1: Gastroenterology. 1980 Mar;78(3):444-7. Related Articles, Links
Colonic conservation of malabsorbed carbohydrate.
Bond JH, Currier BE, Buchwald H, Levitt MD.
[14C]Sucrose absorption was studied in 4 healthy controls and 4 patients after jejunoileal bypass using an ileal perfusion technique which made it possible to distinguish 14C-absorption in the small bowel from that occurring in the colon. Healthy controls failed to absorb 2--4% of a 50-g dose of [14C]sucrose in the small bowel; however, virtually none of the [14C] appeared in feces in a dialyzable form with appreciable osmotic activity. In bypass patients, the small bowel failed to absorb 29--84% of the 50-g dose of [14C]sucrose. Approximately two-thirds of the nonabsorbed [14C] was in the form of sucrose and the remainder was nearly all present as monosaccharides. A mean of only 42% of the [14C] Not absorbed in the small bowel appeared in the feces and only about one-third of this fecal [14C] was in a dialyzable form with appreciable osmotic activity. Thus, the colon plays an important role in carbohydrate malabsorption by salvaging carbohydrate and reducing osmotic activity of the nonabsorbed sugar. This conlonic function appears to depend upon bacterial metabolism of the carbohydrate, and individual variations in diarrhea and weight loss associated with carbohydrate malabsorption could reflect individual differences in the bacterial flora of the colon.
PMID: 7351283 [PubMed - indexed for MEDLINE]
This study shows that Patients who had undergone jejunoileal bypass surgery had much lower rates of Oxalobacter formigenes.
1: J Nutr. 1986 Mar;116(3):455-60.
Oxalate degradation by gastrointestinal bacteria from humans.
Allison MJ, Cook HM, Milne DB, Gallagher S, Clayman RV.
Anaerobic bacteria that metabolize oxalic acid have only recently been isolated from the rumen and from other gastrointestinal habitats. They constitute a new genus and species, Oxalobacter formigenes. This report presents the first comparison of cultural counts of these organisms from human feces and indicates that numbers as high as 10(7)/g may be present in feces from normal humans. Rates of oxalate degradation by mixed bacterial populations in feces from seven normal humans ranged from 0.1 to 4.8 mumol/(g X h). With fecal samples from eight patients that had undergone jejunoileal bypass surgery, rates were much lower [0-0.006 mumol/(g X h)]. We propose that oxalic acid degradation by Oxalobacter formigenes may influence absorption of oxalate from the intestine and that lower rates or lack of oxalate degradation in the colons of jejunoileal bypass patients may contribute to the increased absorption of dietary oxalate and the hyperoxaluria commonly associated with such patients.
PMID: 3950772 [PubMed - indexed for MEDLINE]
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Research articles that report that Lactic acid bacteria such as acidophilus reduce oxalates.
http://www.gutresearch.com/9acido.html